Communications Biology (Dec 2022)

A statistical framework for high-content phenotypic profiling using cellular feature distributions

  • Yanthe E. Pearson,
  • Stephan Kremb,
  • Glenn L. Butterfoss,
  • Xin Xie,
  • Hala Fahs,
  • Kristin C. Gunsalus

DOI
https://doi.org/10.1038/s42003-022-04343-3
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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A high-content screening assay based on a comprehensive set of cytological features, together with a robust statistical analysis workflow for profiling broad-based cellular phenotypic responses to small molecules or genetic perturbations.