FEMALE SEX HORMONES AS MODULATORS OF GENDER DIFFERENCES IN RESPONSE TO PHARMACOTHERAPY OF CARDIOVASCULAR DISEASES

Abstract

The cardiovascular morbidity in developed countries has decreased, but only in men and it has increased in women. The risk of cardiovascular diseases in premenopausal women is 2-4 times less than this in men. A role of hormone replacement therapy for postmenopausal women in primary and secondary prevention of cardiovascular diseases is reviewed. The results of retrospective and plaсebo-controlled trials are presented. Cellular cardioprotective mechanisms of action of female sex hormones are shown.

Keywords

• заместительная гормональная терапия
• ишемическая болезнь сердца
• артериальная гипертония
• хроническая сердечная недостаточность
• атеросклероз