Geometrically encoded SERS nanobarcodes for the logical detection of nasopharyngeal carcinoma-related progression biomarkers

Duo Lin; Chang-Lin Hsieh; Keng-Chia Hsu; Pei-Hsuan Liao; Sufang Qiu; Tianxun Gong; Ken-Tye Yong; Shangyuan Feng; Kien Voon Kong

doi:10.1038/s41467-021-23789-3

Nature Communications (Jun 2021)

Geometrically encoded SERS nanobarcodes for the logical detection of nasopharyngeal carcinoma-related progression biomarkers

Duo Lin,
Chang-Lin Hsieh,
Keng-Chia Hsu,
Pei-Hsuan Liao,
Sufang Qiu,
Tianxun Gong,
Ken-Tye Yong,
Shangyuan Feng,
Kien Voon Kong

Affiliations

Duo Lin: Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University
Chang-Lin Hsieh: Department of Chemistry, National Taiwan University
Keng-Chia Hsu: Department of Chemistry, National Taiwan University
Pei-Hsuan Liao: Department of Chemistry, National Taiwan University
Sufang Qiu: Fujian Medical University Cancer Hospital, Fujian Cancer Hospital
Tianxun Gong: State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Electronic Science and Engineering (National Exemplary School of Microelectronics), University of Electronic Science and Technology of China
Ken-Tye Yong: School of Biomedical Engineering, The University of Sydney
Shangyuan Feng: Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University
Kien Voon Kong: Department of Chemistry, National Taiwan University

DOI: https://doi.org/10.1038/s41467-021-23789-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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SERS assays have potential for multiplexed detection of biomarkers but differentiation of SERS tags remains a challenge. Here, the authors report the creation of 14 distinct geometrically controlled metal carbonyl tags and demonstrate multiplexed detection of nasopharyngeal carcinoma biomarkers from patient blood.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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