An Experimental Investigation on Indoor Air Pressure Performance of Multi-compartment Pharmacy Cleanroom under Local Fume Hood Operating Scenario

Abstract

The control of indoor air pressure is very important in cleanroom operation, because of its sensitiveness of the risks from contaminants dispersion. Especially in pharmaceutical cleanrooms, since there always exist multiple compartments, the parametric stability of indoor air pressure is the key-point of operation control. When a fume hood in cleanroom running, the exhaust air volume changes greatly and then cause indoor pressure oscillating. Meanwhile, this scenario of fume hood running is often occurred because of manufacturing process need. However, the performance pattern of pressure is not clear when fume hood switches on or off. Therefore, the control strategy might be inefficient and even invalid. In this paper, the performance of indoor air pressure of multi-compartment cleanrooms under fume hood operating scenario is measured and analysed by experimental investigation method. The works of this paper might help understanding the performance of pressure variation in cleanrooms when disturbances occur and change. And the conclusions of this paper could be references for the design and operation strategies of multi-compartment cleanrooms.