Ir-Catalyzed <i>ortho</i>-C-H Borylation of Aromatic C(sp²)-H Bonds of Carbocyclic Compounds Assisted by <i>N</i>-Bearing Directing Groups

Abstract

C-H borylation is a powerful strategy for the construction of C-B bonds due to the synthetic versatility of C-B bonds. Various transition metals affect the powerful functionalization of C-H bonds, of which Ir is the most common. Substrate-directed methods have enabled directed Ir-catalyzed C-H borylation at the ortho position. Amongst the powerful directing groups in Ir-catalyzed C-H borylation are N-containing carbocyclic systems. This review covers substrate-directed Ir-catalyzed ortho-C-H borylation of aromatic C(sp2)-H bonds in N-containing carbocyclic compounds, such as anilines, amides, benzyl amines, hydrazones, and triazines.

Keywords

• Ir-catalysis
• C-H functionalization
• C-H borylation
• directing groups
• <i>N</i>-bearing directing groups
• directed C-H borylation