NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Hani Alrefai; Khalid Muhammad; Ronald Rudolf; Duong Anh Thuy Pham; Stefan Klein-Hessling; Amiya K. Patra; Andris Avots; Valesca Bukur; Ugur Sahin; Stefan Tenzer; Matthias Goebeler; Andreas Kerstan; Edgar Serfling

doi:10.1038/ncomms11724

Nature Communications (May 2016)

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Hani Alrefai,
Khalid Muhammad,
Ronald Rudolf,
Duong Anh Thuy Pham,
Stefan Klein-Hessling,
Amiya K. Patra,
Andris Avots,
Valesca Bukur,
Ugur Sahin,
Stefan Tenzer,
Matthias Goebeler,
Andreas Kerstan,
Edgar Serfling

Affiliations

Hani Alrefai: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Khalid Muhammad: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Ronald Rudolf: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Duong Anh Thuy Pham: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Stefan Klein-Hessling: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Amiya K. Patra: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Andris Avots: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University
Valesca Bukur: TRON gGmbH-Translational Oncology, Johannes-Gutenberg-University Medical Center
Ugur Sahin: TRON gGmbH-Translational Oncology, Johannes-Gutenberg-University Medical Center
Stefan Tenzer: Institute for Immunology, University Medical Center, Johannes-Gutenberg-University
Matthias Goebeler: Department of Dermatology, Venereology and Allergology, University Hospital Würzburg
Andreas Kerstan: Department of Dermatology, Venereology and Allergology, University Hospital Würzburg
Edgar Serfling: Department of Molecular Pathology, Institute of Pathology, Julius-Maximilians-University

DOI: https://doi.org/10.1038/ncomms11724
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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