Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems
Sergey Brezgin,
Anastasiya Kostyusheva,
Ekaterina Bayurova,
Elena Volchkova,
Vladimir Gegechkori,
Ilya Gordeychuk,
Dieter Glebe,
Dmitry Kostyushev,
Vladimir Chulanov
Affiliations
Sergey Brezgin
National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia
Anastasiya Kostyusheva
National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia
Ekaterina Bayurova
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 108819 Moscow, Russia
Elena Volchkova
Department of Infectious Diseases, Sechenov University, 119991 Moscow, Russia
Vladimir Gegechkori
Department of Pharmaceutical and Toxicological Chemistry, Sechenov University, 119991 Moscow, Russia
Ilya Gordeychuk
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 108819 Moscow, Russia
Dieter Glebe
National Reference Center for Hepatitis B Viruses and Hepatitis D Viruses, Institute of Medical Virology, Justus Liebig University of Giessen, 35392 Giessen, Germany
Dmitry Kostyushev
National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia
Vladimir Chulanov
National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia
Viral infections cause a variety of acute and chronic human diseases, sometimes resulting in small local outbreaks, or in some cases spreading across the globe and leading to global pandemics. Understanding and exploiting virus–host interactions is instrumental for identifying host factors involved in viral replication, developing effective antiviral agents, and mitigating the severity of virus-borne infectious diseases. The diversity of CRISPR systems and CRISPR-based tools enables the specific modulation of innate immune responses and has contributed impressively to the fields of virology and immunology in a very short time. In this review, we describe the most recent advances in the use of CRISPR systems for basic and translational studies of virus–host interactions.
