NATIONWIDE OVERVIEW OF CARDIOMEMS WIRELESS PRESSURE MONITORING: IMPLEMENTATION AND PRACTICE IN THE UNITED STATES, 2019-2020

Abstract

Therapeutic Area: Other: Heart failure treatment modalities in women Background: Heart failure (HF) affects 64 million people globally and is a leading cause of hospitalizations. Since the FDA approved the CardioMEMS device, real-world data on its usage, complications, and in-hospital mortality are limited. Current literature lacks analysis of gender disparities in wireless pressure monitoring. Our study used the National Inpatient Sample (NIS) to evaluate clinical outcomes after device implantation and investigate gender disparities in usage and outcomes. Methods: We analyzed the 2019-2020 NIS database. We removed 112 cases due to patients being transferred out to avoid duplicates and excluded those with missing variables. Patients implanted with wireless pressure monitoring devices were identified using ICD-10 codes. Statistical analysis was performed using STATA 17. Categorical variables were compared with chi-square tests and linear regression for continuous variables. Logistic and linear regression adjusted for potential confounders, and the Charlson Comorbidity Index accounted for comorbid conditions. Results: Between 2019 and 2020, there were 779 hospitalizations for pulmonary artery sensor insertions, with 220 (28.2%) being female patients. No significant disparities in baseline characteristics were found. The overall inpatient mortality rate was 4.5% (35/779). After adjusting for confounding factors, female inpatient mortality rates didn't significantly differ from males (aOR 3.63, 95% CI 0.40-32.6). Mechanical ventilation (aOR 0.91, 95% CI 0.24-3.47) and hemodialysis initiation (aOR 3.96, 95% CI 0.52-29.8) also showed no significant differences between genders. Hospital stay length was comparable (13.1 vs. 10.1 days, p=0.20); however, female patients had lower total hospital charges ($198,882 vs. $350,304, p<0.04). (Table 1 and Table 2) Conclusions: The study found no significant gender differences in in-hospital outcomes for patients undergoing pulmonary artery sensor insertion during 2019-2020, but lower hospital charges for females suggest potential disparities. Limitations include relying on a single database and focusing on in-hospital outcomes. Future studies should consider long-term outcomes, such as readmission rates and post-discharge mortality. In conclusion, findings indicate potential gender disparities in healthcare services for patients receiving wireless pressure monitoring device implantation, requiring further investigation and solutions.