Nature Communications (Apr 2020)

Structural morphing in a symmetry-mismatched viral vertex

  • Qianglin Fang,
  • Wei-Chun Tang,
  • Pan Tao,
  • Marthandan Mahalingam,
  • Andrei Fokine,
  • Michael G. Rossmann,
  • Venigalla B. Rao

DOI
https://doi.org/10.1038/s41467-020-15575-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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In icosahedral viruses, a symmetry-mismatched portal vertex is assembled by inserting a 12-fold-symmetric portal complex into a 5-fold-symmetric capsid environment. Here, the authors report a near-atomic-resolution in situ cryo-electron microscopy structure of this symmetrically mismatched viral vertex from bacteriophage T4.