The role of B cells in COVID-19 infection and vaccination

Shiru Chen; Shiru Chen; Fei Guan; Fabio Candotti; Kamel Benlagha; Niels Olsen Saraiva Camara; Andres A. Herrada; Louisa K. James; Jiahui Lei; Heather Miller; Masato Kubo; Qin Ning; Chaohong Liu

doi:10.3389/fimmu.2022.988536

Frontiers in Immunology (Aug 2022)

The role of B cells in COVID-19 infection and vaccination

Shiru Chen,
Shiru Chen,
Fei Guan,
Fabio Candotti,
Kamel Benlagha,
Niels Olsen Saraiva Camara,
Andres A. Herrada,
Louisa K. James,
Jiahui Lei,
Heather Miller,
Masato Kubo,
Qin Ning,
Chaohong Liu

Affiliations

Shiru Chen: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China
Shiru Chen: Department of Internal Medicine, The Division of Gastroenterology and Hepatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Fei Guan: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China
Fabio Candotti: Division of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Kamel Benlagha: Institut de Recherche Saint-Louis, Université de Paris, Paris, France
Niels Olsen Saraiva Camara: Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil
Andres A. Herrada: Lymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Talca, Chile
Louisa K. James: Centre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United Kingdom
Jiahui Lei: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China
Heather Miller: Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States
Masato Kubo: Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), Rikagaku Kenkyusho, Institute of Physical and Chemical Research (RIKEN) Yokohama Institute, Yokohama, Kanagawa, Japan
Qin Ning: 0Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Chaohong Liu: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, China

DOI: https://doi.org/10.3389/fimmu.2022.988536
Journal volume & issue: Vol. 13

Abstract

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B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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