Platelets, mean platelet volume, lymphocytes, leukocytes, and ratios of them altered in patients with hepatitis B virus‐related decompensated cirrhosis

Abstract

Abstract Blood routine examination is an inexpensive, routinely performed clinical project, which includes many blood parameters. Hepatitis B virus (HBV) infection may have significant effects on blood parameters in decompensated patients with hepatitis B cirrhosis. However, details were not quite clear yet. A total of 207 HBV‐related decompensated cirrhosis (HBV‐DeCi) patients were included in this retrospective analysis. The included patients were subdivided into three groups: 44 patients with HBsAg, HBeAg, and HbcAb positive were set as Group I; 122 patients with HBsAg, HBeAb, and HbcAb positive were set as Group II; 41 patients with HBsAb, HBeAb, and HbcAb positive were set as Group III. Blood parameters, including platelet (PLT) count, mean platelet volume (MPV), lymphocyte count, leukocyte count and MPV/lymphocyte ratio (MPVLR), lymphocyte/ leukocyte ratio (LLR), platelet/leukocyte ratio (PLR) were analyzed respectively. The correlation between mentioned parameters and the HBV infection were characterized respectively. The values of PLT, MPVLR, and PLR in Group I and II were lower than that in Group III. Group II has a much higher LLR than that in Group I and III. HBV does have significantly effect on blood parameters in HBV‐DeCi patients. Effective treatment must be applied to achieve cirrhosis recompensation promptly.

Keywords

• blood parameters
• decompensated cirrhosis
• hepatitis B virus
• inflammation