Gating mechanism of hyperpolarization-activated HCN pacemaker channels

Rosamary Ramentol; Marta E. Perez; H. Peter Larsson

doi:10.1038/s41467-020-15233-9

Nature Communications (Mar 2020)

Gating mechanism of hyperpolarization-activated HCN pacemaker channels

Rosamary Ramentol,
Marta E. Perez,
H. Peter Larsson

Affiliations

Rosamary Ramentol: Department of Physiology and Biophysics, University of Miami
Marta E. Perez: Department of Physiology and Biophysics, University of Miami
H. Peter Larsson: Department of Physiology and Biophysics, University of Miami

DOI: https://doi.org/10.1038/s41467-020-15233-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 7

Abstract

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain. Here authors reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between the voltage sensor and the pore domain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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