Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase

Abstract

Rho-family GTPase Rac1 activates the WAVE complex (WRC) to promote Arp2/3-mediated actin assembly in various processes. Here, the authors determined cryo-EM structures of WRC bound to Rac1 in different states, revealing how Rac1 binding activates WRC.