Association of Phosphatase and Tensin Homologue-induced Putative Kinase 1 with Refractory Diabetic Wound Healing: a Review

Abstract

Chronic and refractory wounds are serious complications of diabetes mellitus, and have no effective treatments. Numerous studies have confirmed that events such as inflammatory response, angiopoiesis and matrix remodeling are closely related to mitochondrial function during diabetic wound healing. Phosphatase and tensin homologue-induced kinase 1 (PINK1) is a serine/threonine protein kinase primarily located in mitochondria, which is involved in regulating mitochondrial autophagy to protect cells from oxidative stress, and plays an important role in regulating inflammatory responses and promoting lipid metabolism. Mutations in the PINK1 gene are closely related to the onset of Parkinson's syndrome. Recent studies also show that PINK1 may be involved in regulating the development of type 2 diabetes. We gave a description of the mechanism of action of PINK1 in regulating diabetic wound healing after reviewing the latest relevant research, and found that existing studies have failed to reveal the molecular mechanism and the time sequence and interaction of signal transduction process involved by PINK1 in different stages of wound healing. Moreover, there is still a lack of in vivo research on PINK1 regulating the healing of refractory diabetic wounds. It is hoped that further clinical research could provide more ideas for the treatment of refractory diabetic wounds.

Keywords

• diabetes mellitus|diabetic refractory wounds|phosphatase and tensin homologue gene induced putative kinase 1|wound repair|review