Conformational ensemble of the human TRPV3 ion channel

Lejla Zubcevic; Mark A. Herzik; Mengyu Wu; William F. Borschel; Marscha Hirschi; Albert S. Song; Gabriel C. Lander; Seok-Yong Lee

doi:10.1038/s41467-018-07117-w

Nature Communications (Nov 2018)

Affiliations

Lejla Zubcevic: Department of Biochemistry, Duke University Medical Center
Mark A. Herzik: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Mengyu Wu: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
William F. Borschel: Department of Biochemistry, Duke University Medical Center
Marscha Hirschi: Department of Biochemistry, Duke University Medical Center
Albert S. Song: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Gabriel C. Lander: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Seok-Yong Lee: Department of Biochemistry, Duke University Medical Center

DOI: https://doi.org/10.1038/s41467-018-07117-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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