Evaluation of bivalent inactivated oil adjuvant African Horse Sickness vaccine in Guinea pigs and mice

Abstract

In this study, neutralizing antibody response in Guinea pigs and mice inoculated by African horse sickness (AHS) bivalent inactivated oil adjuvant vaccine was similar when compared serologically with that in horse. Therefore, using G. pigs and mice may be a method of great value in potency test for routine immunization. Potency test of the prepared vaccine using an immunization challenge protocol in adult mice was studied, using challenge virus with 100, 50 and 25 LD50. The highest protection level (95%) was with the dilution of 50 LD50/0.05 ml

Keywords

• evaluation; bivalent; inactivated; oil; african; horse; sickness; vaccine; pigs; mice; guinea