Nature Communications (Sep 2021)
Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
- Markus Maerker,
- Maike Getwan,
- Megan E. Dowdle,
- Jason C. McSheene,
- Vanessa Gonzalez,
- José L. Pelliccia,
- Danielle S. Hamilton,
- Valeria Yartseva,
- Charles Vejnar,
- Melanie Tingler,
- Katsura Minegishi,
- Philipp Vick,
- Antonio J. Giraldez,
- Hiroshi Hamada,
- Rebecca D. Burdine,
- Michael D. Sheets,
- Martin Blum,
- Axel Schweickert
Affiliations
- Markus Maerker
- University of Hohenheim, Institute of Biology, Department of Zoology
- Maike Getwan
- University of Zurich, Institute of Anatomy
- Megan E. Dowdle
- Department of Biomolecular Chemistry, University of Wisconsin
- Jason C. McSheene
- Department of Molecular Biology, Princeton University
- Vanessa Gonzalez
- Department of Molecular Biology, Princeton University
- José L. Pelliccia
- Department of Molecular Biology, Princeton University
- Danielle S. Hamilton
- Department of Molecular Biology, Princeton University
- Valeria Yartseva
- Department of Genetics, Yale University School of Medicine
- Charles Vejnar
- Department of Genetics, Yale University School of Medicine
- Melanie Tingler
- University of Hohenheim, Institute of Biology, Department of Zoology
- Katsura Minegishi
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Philipp Vick
- University of Hohenheim, Institute of Biology, Department of Zoology
- Antonio J. Giraldez
- Department of Genetics, Yale University School of Medicine
- Hiroshi Hamada
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Rebecca D. Burdine
- Department of Molecular Biology, Princeton University
- Michael D. Sheets
- Department of Biomolecular Chemistry, University of Wisconsin
- Martin Blum
- University of Hohenheim, Institute of Biology, Department of Zoology
- Axel Schweickert
- University of Hohenheim, Institute of Biology, Department of Zoology
- DOI
- https://doi.org/10.1038/s41467-021-25464-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.
