Nature Communications (Feb 2019)
The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans
Abstract
How dietary β-mannans are utilized by gut Gram-positive bacteria is unclear. Here, the authors uncover the enzymatic pathway for β-mannan metabolism in Roseburia intestinalis and show that these polysaccharides promote beneficial gut bacteria, highlighting a potential for β-mannan-based therapeutic interventions.