Nature Communications (Feb 2019)

The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans

  • Sabina Leanti La Rosa,
  • Maria Louise Leth,
  • Leszek Michalak,
  • Morten Ejby Hansen,
  • Nicholas A. Pudlo,
  • Robert Glowacki,
  • Gabriel Pereira,
  • Christopher T. Workman,
  • Magnus Ø. Arntzen,
  • Phillip B. Pope,
  • Eric C. Martens,
  • Maher Abou Hachem,
  • Bjørge Westereng

DOI
https://doi.org/10.1038/s41467-019-08812-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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How dietary β-mannans are utilized by gut Gram-positive bacteria is unclear. Here, the authors uncover the enzymatic pathway for β-mannan metabolism in Roseburia intestinalis and show that these polysaccharides promote beneficial gut bacteria, highlighting a potential for β-mannan-based therapeutic interventions.