Progress of ferroptosis mechanism and application in lung cancer therapy

Abstract

Ferroptosis is a newly discovered mechanism of cell death characterized by accumulation of iron dependent lipid peroxidation and reactive oxygen species, which is different from apoptosis, necrosis and autophagy in morphology and biochemical findings. It is involved in the occurrence and development of lung cancer, so inducing ferroptosis seems to become a new strategy for anti-lung cancer therapy. This review includes the followings: mechanism of ferroptosis from the aspects of iron metabolism, amino acid and glutathione metabolism and lipid metabolism; its effects on lung cancer occurrence and progression, chemotherapy resistance, radiation resistance and immunotherapy respectively, in order to update information on ferroptosis and thus provides a new direction and new strategy for lung cancer treatment.

Keywords

• programmed cell death|ferroptosis|biochemical process|lung cancer|lung cancer therapy