The Role of Lipoperoxidation Processes in Structural and Functional Disorganization of Biological Systems in Dynamics of Bacterial Endotoxicosis

Abstract

The purpose of the study was to investigate the pathogenetic interrelation between the intensity of lipoperoxidation and pathomorphological changes in organs that are responsible for toxin inactivation and elimination (liver, kidneys, bowels) in dynamics of intoxication caused by Yersinia pestis lipopolysaccharide (LPS). We have demonstrated that distrophic and necrobiotic changes as well as microcirculation disturbances in the organs progressed as lipoperoxidation products in homogenates and blood accumulated. Noted abnormalities correlated with severity of clinical manifestations of the pathology. The results obtained in this study allow to suppose that activation of free radical oxidation in dynamics of plague intoxication is an efferent segment of cytopathogenic effects of Y. pestis LPS.

Keywords

• y. pestislps
• bacterial endotoxicosis
• lipoperoxidation