mBio
(Apr 2021)
<i>In Vivo</i>
Antigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection
Helena Strand Clemmensen,
Jean-Yves Dube,
Fiona McIntosh,
Ida Rosenkrands,
Gregers Jungersen,
Claus Aagaard,
Peter Andersen,
Marcel A. Behr,
Rasmus Mortensen
Affiliations
Helena Strand Clemmensen
ORCiD Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Jean-Yves Dube
Department of Microbiology and Immunology, McGill University, Montréal, Canada
Fiona McIntosh
Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada
Ida Rosenkrands
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Gregers Jungersen
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Claus Aagaard
ORCiD Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Peter Andersen
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Marcel A. Behr
ORCiD Department of Microbiology and Immunology, McGill University, Montréal, Canada
Rasmus Mortensen
ORCiD Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
DOI
https://doi.org/10.1128/mBio.00226-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
Tuberculosis, caused by Mtb, constitutes a global health crisis of massive proportions, and the impact of the current coronavirus disease 2019 (COVID-19) pandemic is expected to cause a rise in tuberculosis-related deaths. Improved vaccines are therefore needed more than ever, but a lack of knowledge on protective immunity hampers their development.
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