Molecular & Cellular Oncology (Nov 2021)

Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing

  • Andrés García-García,
  • Ivan Martin

DOI
https://doi.org/10.1080/23723556.2021.2007030
Journal volume & issue
Vol. 8, no. 6

Abstract

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We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing platform for pharmaceutical research and patient-personalized medicine.

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