Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex

Scientific Reports. 2019;9(1):1-15 DOI 10.1038/s41598-019-56926-6

 

Journal Homepage

Journal Title: Scientific Reports

ISSN: 2045-2322 (Online)

Publisher: Nature Publishing Group

LCC Subject Category: Medicine | Science

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Michael G. K. Brunk (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Katrina E. Deane (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Martin Kisse (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Matthias Deliano (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Silvia Vieweg (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Frank W. Ohl (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Michael T. Lippert (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

Max F. K. Happel (Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 20 weeks

 

Abstract | Full Text

Abstract Reward associations during auditory learning induce cortical plasticity in the primary auditory cortex. A prominent source of such influence is the ventral tegmental area (VTA), which conveys a dopaminergic teaching signal to the primary auditory cortex. Yet, it is unknown, how the VTA influences cortical frequency processing and spectral integration. Therefore, we investigated the temporal effects of direct optogenetic stimulation of the VTA onto spectral integration in the auditory cortex on a synaptic circuit level by current-source-density analysis in anesthetized Mongolian gerbils. While auditory lemniscal input predominantly terminates in the granular input layers III/IV, we found that VTA-mediated modulation of spectral processing is relayed by a different circuit, namely enhanced thalamic inputs to the infragranular layers Vb/VIa. Activation of this circuit yields a frequency-specific gain amplification of local sensory input and enhances corticocortical information transfer, especially in supragranular layers I/II. This effects persisted over more than 30 minutes after VTA stimulation. Altogether, we demonstrate that the VTA exhibits a long-lasting influence on sensory cortical processing via infragranular layers transcending the signaling of a mere reward-prediction error. We thereby demonstrate a cellular and circuit substrate for the influence of reinforcement-evaluating brain systems on sensory processing in the auditory cortex.