Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review

Yihan Wang; Yihan Wang; Shutao Zhang; Shutao Zhang; Bin’en Nie; Bin’en Nie; Xinhua Qu; Xinhua Qu; Bing Yue; Bing Yue

doi:10.3389/fbioe.2022.895288

Frontiers in Bioengineering and Biotechnology (May 2022)

Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review

Yihan Wang,
Yihan Wang,
Shutao Zhang,
Shutao Zhang,
Bin’en Nie,
Bin’en Nie,
Xinhua Qu,
Xinhua Qu,
Bing Yue,
Bing Yue

Affiliations

Yihan Wang: Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Yihan Wang: Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Shutao Zhang: Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Shutao Zhang: Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Bin’en Nie: Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Bin’en Nie: Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Xinhua Qu: Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Xinhua Qu: Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Bing Yue: Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Bing Yue: Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

DOI: https://doi.org/10.3389/fbioe.2022.895288
Journal volume & issue: Vol. 10

Abstract

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Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In order to fabricate an antibacterial bio-functional surface, modifications of PEEK had been widely investigated. This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial. We will begin with reviewing different approaches, such as surface-coating modifications and controlled release of antimicrobials. Furthermore, blending modifications and 3D printing technology were discussed. Finally, we compare the effects among different approaches. We aimed to provide an in-depth understanding of the antibacterial modification and optimize the design of the PEEK orthopedic implant.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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