Genetics and Molecular Biology ()

Papillomaviruses: a systematic review

  • Rodrigo Pinheiro Araldi,
  • Suely Muro Reis Assaf,
  • Rodrigo Franco de Carvalho,
  • Márcio Augusto Caldas Rocha de Carvalho,
  • Jacqueline Mazzuchelli de Souza,
  • Roberta Fiusa Magnelli,
  • Diego Grando Módolo,
  • Franco Peppino Roperto,
  • Rita de Cassia Stocco,
  • Willy Beçak

DOI
https://doi.org/10.1590/1678-4685-gmb-2016-0128
Journal volume & issue
no. 0

Abstract

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Abstract In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds. To overcome the problem, the vaccines that we have been developing involve recombinant DNA technology, aiming at prophylactic and therapeutic procedures. It is important to point out that these strategies can be used as models for innovative procedures against HPV, as this virus is the main causal agent of cervical cancer, the second most fatal cancer in women.

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