Applied Sciences (Apr 2023)

Preclinical Evaluation of Bioactive Scaffolds for the Treatment of Mandibular Critical-Sized Bone Defects: A Systematic Review

  • Jana Desnica,
  • Sanja Vujovic,
  • Dragana Stanisic,
  • Irena Ognjanovic,
  • Bojan Jovicic,
  • Momir Stevanovic,
  • Gvozden Rosic

DOI
https://doi.org/10.3390/app13084668
Journal volume & issue
Vol. 13, no. 8
p. 4668

Abstract

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This systematic review evaluated current in vivo research on regenerating critical-sized mandibular defects and discussed methodologies for mandibular bone tissue engineering. Out of the 3650 articles initially retrieved, 88 studies were included, and all studies that used a scaffold reported increased bone formation compared to negative controls. Combining scaffolds with growth factors and mesenchymal stem cells improved bone formation and healing. Bone morphogenic proteins were widely used and promoted significant bone formation compared to controls. However, discrepancies between studies exist due to the various methodologies and outcome measures used. The use of scaffolds with bioactive molecules and/or progenitor cells enhances success in mandibular bone engineering. Scaffold-based mandibular bone tissue engineering could be introduced into clinical practice due to its proven safety, convenience, and cost-effectiveness.

Keywords