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Modeling amyloids in bacteria

Microbial Cell Factories. 2012;11(1):166 DOI 10.1186/1475-2859-11-166

 

Journal Homepage

Journal Title: Microbial Cell Factories

ISSN: 1475-2859 (Online)

Publisher: BMC

LCC Subject Category: Science: Microbiology

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Villar-Piqué Anna

Ventura Salvador

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 10 weeks

 

Abstract | Full Text

<p>Abstract</p> <p>An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.</p>