PLoS ONE (2013-01-01)

Aortic stiffness in lone atrial fibrillation: a novel risk factor for arrhythmia recurrence.

  • Dennis H Lau,
  • Melissa E Middeldorp,
  • Anthony G Brooks,
  • Anand N Ganesan,
  • Kurt C Roberts-Thomson,
  • Martin K Stiles,
  • Darryl P Leong,
  • Hany S Abed,
  • Han S Lim,
  • Christopher X Wong,
  • Scott R Willoughby,
  • Glenn D Young,
  • Jonathan M Kalman,
  • Walter P Abhayaratna,
  • Prashanthan Sanders

Journal volume & issue
Vol. 8, no. 10
p. e76776


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BackgroundRecent community-based research has linked aortic stiffness to the development of atrial fibrillation. We posit that aortic stiffness contributes to adverse atrial remodeling leading to the persistence of atrial fibrillation following catheter ablation in lone atrial fibrillation patients, despite the absence of apparent structural heart disease. Here, we aim to evaluate aortic stiffness in lone atrial fibrillation patients and determine its association with arrhythmia recurrence following radio-frequency catheter ablation.MethodsWe studied 68 consecutive lone atrial fibrillation patients who underwent catheter ablation procedure for atrial fibrillation and 50 healthy age- and sex-matched community controls. We performed radial artery applanation tonometry to obtain central measures of aortic stiffness: pulse pressure, augmentation pressure and augmentation index. Following ablation, arrhythmia recurrence was monitored at months 3, 6, 9, 12 and 6 monthly thereafter.ResultsCompared to healthy controls, lone atrial fibrillation patients had significantly elevated peripheral pulse pressure, central pulse pressure, augmentation pressure and larger left atrial dimensions (all PConclusionAortic stiffness is an important risk factor in patients with lone atrial fibrillation and contributes to higher atrial fibrillation recurrence following catheter ablation procedure.