Recent advances in using liposomes for delivery of nucleic acid-based therapeutics
Hamdi Nsairat,
Walhan Alshaer,
Fadwa Odeh,
Ezzaldeen Esawi,
Dima Khater,
Abeer Al Bawab,
Mohamed El-Tanani,
Abdalla Awidi,
Mohammad S. Mubarak
Affiliations
Hamdi Nsairat
Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al–Ahliyya Amman University, Amman 19328, Jordan; Corresponding authors.
Walhan Alshaer
Cell Therapy Center, the University of Jordan, Amman 11942, Jordan; Corresponding authors.
Fadwa Odeh
Department of Chemistry, the University of Jordan, Amman 11942, Jordan
Ezzaldeen Esawi
Cell Therapy Center, the University of Jordan, Amman 11942, Jordan
Dima Khater
Department of Chemistry, Faculty of Arts and Science, Applied Science Private University, Amman 11931, Jordan
Abeer Al Bawab
Department of Chemistry, the University of Jordan, Amman 11942, Jordan; Hamdi Mango Center, The University of Jordan, Amman 11942, Jordan
Mohamed El-Tanani
Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al–Ahliyya Amman University, Amman 19328, Jordan
Abdalla Awidi
Cell Therapy Center, the University of Jordan, Amman 11942, Jordan; Department of Internal Medicine, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan; Department of Hematology and Oncology, Jordan University Hospital, The University of Jordan, Amman 11942, Jordan
Mohammad S. Mubarak
Department of Chemistry, the University of Jordan, Amman 11942, Jordan
Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class of therapeutics may change the field of disease treatment and personalized medicine since it can cure diseases. However, drug delivery systems are crucial for these therapeutics to fulfill their potential. Liposomes have long been considered ideal platforms for systemic drugs delivery. Considering the development in cancer therapeutics, this work emphases on the current advancements in liposomes’ Nano-formulations, functionalization, and design and how it has been applied to nucleic acid therapeutics. Accordingly, this review covers the literature that deals with liposomes in nucleic acid therapy.
