Metabolic phenotyping of hand automatisms in mesial temporal lobe epilepsy

Abstract

Highlights 1. Metabolic pattern analysis allowed allocation of the symptomatogenic zone (EZ) and brain network of hand automatisms (HA) in mesial temporal lobe epilepsy (mTLE). 2. The involved network of bilateral HA was larger than the unilateral one, probably due to the occurrence of contralateral dystonic posturing. 3. Increased metabolic synchronization within supplementary motor area (SMA) and middle cingulate cortex (MCC) regions were engaged in the representation and modulation of HA, suggesting these regions as the EZ for HA.

Keywords

• Symptomatogenic zone
• Metabolic network
• Hand automatism
• Temporal lobe epilepsy
• Synchronization