Spin 1/2 quantum spin chains represent the prototypical model for coupled two-level systems. Consequently, they offer a fertile playground for both fundamental and technological applications ranging from the theory of thermalization to quantum computation. Recently, it has been shown that interesting phenomena are associated to the boundary conditions imposed on the quantum spin chains via the so-called topological frustration. In this work, we analyze the effects of such frustration on a few-spin system, with a particular focus on the strong even–odd effects induced in the ground-state energy. We then implement a topologically frustrated quantum spin chain on a quantum computer to show that our predictions are visible on current quantum hardware platforms.