OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

Aleksandra Klimas; Christina M. Ambrosi; Jinzhu Yu; John C. Williams; Harold Bien; Emilia Entcheva

doi:10.1038/ncomms11542

Nature Communications (May 2016)

OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

Aleksandra Klimas,
Christina M. Ambrosi,
Jinzhu Yu,
John C. Williams,
Harold Bien,
Emilia Entcheva

Affiliations

Aleksandra Klimas: Department of Biomedical Engineering, Stony Brook University
Christina M. Ambrosi: Department of Biomedical Engineering, Stony Brook University
Jinzhu Yu: Department of Biomedical Engineering, Stony Brook University
John C. Williams: Department of Biomedical Engineering, Stony Brook University
Harold Bien: Department of Biomedical Engineering, Stony Brook University
Emilia Entcheva: Department of Biomedical Engineering, Stony Brook University

DOI: https://doi.org/10.1038/ncomms11542
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The efficiency of preclinical drug testing and characterization of cellular function can be improved through the use of optogenetic tools. Here Klimas et al. present and validate OptoDyCE, a fully automated system for all-optical high-throughput cardiac electrophysiology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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