Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2

James B. Studd; Jayaram Vijayakrishnan; Minjun Yang; Gabriele Migliorini; Kajsa Paulsson; Richard S. Houlston

doi:10.1038/ncomms14616

Nature Communications (Mar 2017)

Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10q21.2

James B. Studd,
Jayaram Vijayakrishnan,
Minjun Yang,
Gabriele Migliorini,
Kajsa Paulsson,
Richard S. Houlston

Affiliations

James B. Studd: Division of Genetics and Epidemiology, The Institute of Cancer Research
Jayaram Vijayakrishnan: Division of Genetics and Epidemiology, The Institute of Cancer Research
Minjun Yang: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Gabriele Migliorini: Division of Genetics and Epidemiology, The Institute of Cancer Research
Kajsa Paulsson: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Richard S. Houlston: Division of Genetics and Epidemiology, The Institute of Cancer Research

DOI: https://doi.org/10.1038/ncomms14616
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Risk for the paediatric cancer high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) has been associated with genetic variants at 10q21.2. Here, the authors characterize this region, establishing a single risk variant and showing its role in dysregulated expression ofARID5B.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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