Pancytopenia, a rare presentation of waldenström's macroglobulinemia: Approach to diagnosis and a brief review of literature

Abstract

Waldenström's macroglobulinemia (WM) is a low-Grade B-cell neoplasm characterized by infiltration of the bone marrow by a lymphoplasmacytic infiltrate along with immunoglobulin M (IgM) monoclonal gammopathy. We report the case of a 70-year-old male who presented with pancytopenia and a relative prominence of lymphoplasmacytoid cells. The patient had no lymphadenopathy or any organomegaly. The diagnosis of WM was made after morphological and immunohistochemical examination of bone marrow of the patient along with IgM and kappa monoclonal band on immunofixation electrophoresis.

Keywords

• immunoglobulin m kappa monoclonality
• pancytopenia
• waldenström's macroglobulinemia