The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened

Metztli Cisneros-Aguirre; Felicia Wednesday Lopezcolorado; Linda Jillianne Tsai; Ragini Bhargava; Jeremy M. Stark

doi:10.1038/s41467-022-31365-6

Nature Communications (Jun 2022)

The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened

Metztli Cisneros-Aguirre,
Felicia Wednesday Lopezcolorado,
Linda Jillianne Tsai,
Ragini Bhargava,
Jeremy M. Stark

Affiliations

Metztli Cisneros-Aguirre: Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope
Felicia Wednesday Lopezcolorado: Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope
Linda Jillianne Tsai: Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope
Ragini Bhargava: Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope
Jeremy M. Stark: Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope

DOI: https://doi.org/10.1038/s41467-022-31365-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

DNAPKcs and its kinase activity are required for blunt DNA break end joining when the bridging factor XLF is weakened, but for homologous recombination and radiation resistance, the influence of DNAPKcs is not further enhanced with loss of XLF.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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