Effectiveness of Trino-IB on rat infected with respiratory syncytial virus

Abstract

The respiratory syncytial virus (RSV) is a common cause of respiratory tract infection. The illness typically begins with a low-grade fever, runny nose, cough and sometimes wheezing. Usage of immunostimulators to prevent infections such as RSV is of great importance. Immunostimulators such Trino-IB are drugs which stimulate immune system by inducing activation or increasing activity of any of its components. Thirty specific pathogen-free Wister rats were put into three groups (10 each). Group A was treated with Trino-IB before and after inoculation with RSV, Group B was inoculated with only RSV and Group C (control) was not given any treatment. Clinical signs, anal temperature were observed daily and rats were sacrificed at day 2, 4, 6, 8 and 10 for histological analysis. Rats in Group B showed more and severe clinical signs of RSV infection alongside histopathological changes of the lungs than the rats in Group A. The results of from the study showed that Trino-IB has effect on the immune system of the rats by suppressing the effect of RSV. The effect of Trino-IB on the infected rat explains the ability of the drug to act as an immune booster as well as to suppress the clinical effect of the virus.

Keywords

• RSV
• Trino-IB
• Wister rat
• immunostimulators
• histopathology