Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

Grigoriy A. Armeev; Anastasiia S. Kniazeva; Galina A. Komarova; Mikhail P. Kirpichnikov; Alexey K. Shaytan

doi:10.1038/s41467-021-22636-9

Nature Communications (Apr 2021)

Histone dynamics mediate DNA unwrapping and sliding in nucleosomes

Grigoriy A. Armeev,
Anastasiia S. Kniazeva,
Galina A. Komarova,
Mikhail P. Kirpichnikov,
Alexey K. Shaytan

Affiliations

Grigoriy A. Armeev: Department of Biology, Lomonosov Moscow State University
Anastasiia S. Kniazeva: Department of Biology, Lomonosov Moscow State University
Galina A. Komarova: Department of Physics, Lomonosov Moscow State University
Mikhail P. Kirpichnikov: Department of Biology, Lomonosov Moscow State University
Alexey K. Shaytan: Department of Biology, Lomonosov Moscow State University

DOI: https://doi.org/10.1038/s41467-021-22636-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Nucleosomes tightly wrap ~147 DNA base pairs around an octamer of histone proteins, but how nucleosome structural dynamics affect genome functioning is not completely clear. Here authors employ all-atom molecular dynamics simulations of nucleosome core particles and observe that octamer dynamics and plasticity enable DNA unwrapping and sliding.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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