Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

• Qin Zhang,
• Dennis K. Jeppesen,
• James N. Higginbotham,
• Michelle Demory Beckler,
• Emily J. Poulin,
• Alex J. Walsh,
• Melissa C. Skala,
• Eliot T. McKinley,
• H. Charles Manning,
• Matthew R. Hight,
• Michael L. Schulte,
• Kimberly R. Watt,
• G. Daniel Ayers,
• Melissa M. Wolf,
• Gabriela Andrejeva,
• Jeffrey C. Rathmell,
• Jeffrey L. Franklin,
• Robert J. Coffey

Affiliations

Qin Zhang

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

Dennis K. Jeppesen

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

James N. Higginbotham

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

Michelle Demory Beckler

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee

Emily J. Poulin

Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee

Alex J. Walsh

Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee; Morgridge Institute for Research, University of Wisconsin, Madison, Wisconsin

Melissa C. Skala

Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee; Morgridge Institute for Research, University of Wisconsin, Madison, Wisconsin

Eliot T. McKinley

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

H. Charles Manning

Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee

Matthew R. Hight

Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Physics and Astronomy, Vanderbilt University Medical Center, Nashville, Tennessee

Michael L. Schulte

Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee

Kimberly R. Watt

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee

G. Daniel Ayers

Biostatistics Center, Vanderbilt University Medical Center, Nashville, Tennessee

Melissa M. Wolf

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee

Gabriela Andrejeva

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee

Jeffrey C. Rathmell

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee

Jeffrey L. Franklin

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee; Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Veterans Affairs Medical Center, Nashville, Tennessee

Robert J. Coffey

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Veterans Affairs Medical Center, Nashville, Tennessee; Corresponding author: