International Journal of General Medicine (Mar 2024)

Value of Absolute Eosinophil Count in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

  • Wang Y,
  • Ma X,
  • Yang Z,
  • Li Q,
  • Zhou Y,
  • Gao F,
  • Wang Z

Journal volume & issue
Vol. Volume 17
pp. 1025 – 1038

Abstract

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Yufei Wang,1,* Xiaoteng Ma,1,* Zhiqiang Yang,1,2 Qiuxuan Li,1 Yujie Zhou,1,3 Fei Gao,1,3 Zhijian Wang1,3 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Ministry of Education, Beijing, People’s Republic of China; 2Cardio-Metabolic Medicine Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3The Key Laboratory of Remodeling-Related Cardiovascular Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhijian Wang; Fei Gao, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, the Key Laboratory of Remodeling-related Cardiovascular Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Anzhen Avenue #2, Chaoyang District, Beijing, 100029, People’s Republic of China, Email [email protected]; [email protected] and Aims: Elevated eosinophils typically indicate hypersensitive inflammation; however, their involvement in cardiovascular events remains incompletely understood. We investigated the association between the absolute eosinophil count (AEC) and major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Additionally, we determine whether the integration of AEC with the SYNTAX II score could improve predictive ability.Methods and Results: The AECs of 1711 patients with ACS undergoing PCI from June 2016 to November 2017 were analyzed on admission. All recruitments were splitted into three groups based on AEC tertiles and 101 participants underwent one or more noteworthy outcomings. The association between AEC and MACCEs (defined as a composite of cardiovascular death, myocardial infarction [MI], and stroke) was tested by Cox proportional-hazards regression analysis. After adjusting for confounders, AEC was independently associated with MACCEs (HR 11.555, 95% CI: 3.318– 40.239). Patients in the lowest AEC tertile (T1) as a reference, those in the higher tertiles had an incrementally higher risk of MACCEs (T3: HR 1.848 95% CI: 1.157– 2.952; P for trend=0.008). Inclusion of AEC enhanced the predictive accuracy of the SYNTAX II score for MACCEs (AUC: from 0.701 [95% CI: 0.646– 0.756] to 0.728 [95% CI: 0.677– 0.780]; DeLong’s test, P = 0.020).Conclusion: AEC is independently linked to MACCEs in ACS patients who underwent PCI, and adds incremental predictive information to the SYNTAX II score.Keywords: absolute eosinophil count, SYNTAX I score, SYNTAX II score, cardiovascular and cerebrovascular events, acute coronary syndrome, percutaneous coronary intervention

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