Nature Communications (Jul 2022)
Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability
- Noemi Gioelli,
- Lisa J. Neilson,
- Na Wei,
- Giulia Villari,
- Wenqian Chen,
- Bernhard Kuhle,
- Manuel Ehling,
- Federica Maione,
- Sander Willox,
- Serena Brundu,
- Daniele Avanzato,
- Grigorios Koulouras,
- Massimiliano Mazzone,
- Enrico Giraudo,
- Xiang-Lei Yang,
- Donatella Valdembri,
- Sara Zanivan,
- Guido Serini
Affiliations
- Noemi Gioelli
- Department of Oncology, University of Torino School of Medicine
- Lisa J. Neilson
- Cancer Research UK Beatson Institute
- Na Wei
- Department of Molecular Medicine, The Scripps Research Institute
- Giulia Villari
- Department of Oncology, University of Torino School of Medicine
- Wenqian Chen
- Department of Molecular Medicine, The Scripps Research Institute
- Bernhard Kuhle
- Department of Molecular Medicine, The Scripps Research Institute
- Manuel Ehling
- Center for Cancer Biology, Department of Oncology, University of Leuven
- Federica Maione
- Department of Oncology, University of Torino School of Medicine
- Sander Willox
- Center for Cancer Biology, Department of Oncology, University of Leuven
- Serena Brundu
- Candiolo Cancer Institute - Fondazione del Piemonte per l’Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)
- Daniele Avanzato
- Department of Oncology, University of Torino School of Medicine
- Grigorios Koulouras
- Cancer Research UK Beatson Institute
- Massimiliano Mazzone
- Center for Cancer Biology, Department of Oncology, University of Leuven
- Enrico Giraudo
- Candiolo Cancer Institute - Fondazione del Piemonte per l’Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)
- Xiang-Lei Yang
- Department of Molecular Medicine, The Scripps Research Institute
- Donatella Valdembri
- Department of Oncology, University of Torino School of Medicine
- Sara Zanivan
- Cancer Research UK Beatson Institute
- Guido Serini
- Department of Oncology, University of Torino School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31904-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Functional vascular tree formation is a key step in many contexts, such as cancer, and Neuropilin1 (NRP1) has been associated with adhesion receptor endocytic turnover. Here, authors show NRP1 and its mini-WARS ligand play a role in reducing endothelial permeability.
