Nature Communications (Jul 2019)
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses
- Yuhang Jiang,
- Cuifeng Li,
- Qian Wu,
- Peng An,
- Laiquan Huang,
- Jia Wang,
- Chen Chen,
- Xi Chen,
- Fan Zhang,
- Li Ma,
- Sanhong Liu,
- Hanqing He,
- Shuyun Xie,
- Yangbai Sun,
- Hanshao Liu,
- Yu Zhan,
- Yu Tao,
- Zhi Liu,
- Xiaohua Sun,
- Yiming Hu,
- Qi Wang,
- Deji Ye,
- Jie Zhang,
- Shanhua Zou,
- Ying Wang,
- Gang Wei,
- Yongzhong Liu,
- Yufang Shi,
- Y. Eugene Chin,
- Yongqiang Hao,
- Fudi Wang,
- Xiaoren Zhang
Affiliations
- Yuhang Jiang
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Cuifeng Li
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Qian Wu
- The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine
- Peng An
- The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine
- Laiquan Huang
- Department of Hematology, The First Affiliated Hospital of Wannan Medical College
- Jia Wang
- The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine
- Chen Chen
- Department of Hematology, Zhongshan Hospital Fudan University
- Xi Chen
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Fan Zhang
- The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine
- Li Ma
- Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Sanhong Liu
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Hanqing He
- Zhejiang Provincial Center for Disease Control and Prevention
- Shuyun Xie
- Zhejiang Provincial Center for Disease Control and Prevention
- Yangbai Sun
- Zhejiang Provincial Center for Disease Control and Prevention
- Hanshao Liu
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Yu Zhan
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Yu Tao
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Zhi Liu
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Xiaohua Sun
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Yiming Hu
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- Qi Wang
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Deji Ye
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Jie Zhang
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Shanhua Zou
- Department of Hematology, Zhongshan Hospital Fudan University
- Ying Wang
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Gang Wei
- Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Yongzhong Liu
- Shanghai Cancer Institute, Shanghai Jiao-Tong University School of Medicine
- Yufang Shi
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Y. Eugene Chin
- CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Yongqiang Hao
- Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine
- Fudi Wang
- The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine
- Xiaoren Zhang
- Affiliated Cancer Hospital & Institute, Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-019-11002-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared to iron-normal controls.
