Nature Communications (Oct 2018)

Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

  • Julia Vaynberg,
  • Koichi Fukuda,
  • Fan Lu,
  • Katarzyna Bialkowska,
  • Yinghua Chen,
  • Edward F. Plow,
  • Jun Qin

DOI
https://doi.org/10.1038/s41467-018-06906-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs in PINCH and Parvin