15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia

Yunfei Xu; Yunfei Xu; Yunfei Xu; Yunfei Xu; Haoduo Qiao; Haoduo Qiao; Haoduo Qiao; Haoduo Qiao; Shun Yang; Lin Zhou; Lin Zhou; Lin Zhou; Lin Zhou; Yao Zhao; Yao Zhao; Yao Zhao; Yao Zhao; Qing Xu; Qing Xu; Qing Xu; Qing Xu; Shuying Miao; Shuying Miao; Dun Yuan; Jie Zhao; Ying Liu; Ying Liu; Ying Liu; Ying Liu

doi:10.3389/fneur.2022.893624

Frontiers in Neurology (May 2022)

15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia

Yunfei Xu,
Yunfei Xu,
Yunfei Xu,
Yunfei Xu,
Haoduo Qiao,
Haoduo Qiao,
Haoduo Qiao,
Haoduo Qiao,
Shun Yang,
Lin Zhou,
Lin Zhou,
Lin Zhou,
Lin Zhou,
Yao Zhao,
Yao Zhao,
Yao Zhao,
Yao Zhao,
Qing Xu,
Qing Xu,
Qing Xu,
Qing Xu,
Shuying Miao,
Shuying Miao,
Dun Yuan,
Jie Zhao,
Ying Liu,
Ying Liu,
Ying Liu,
Ying Liu

Affiliations

Yunfei Xu: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Yunfei Xu: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Yunfei Xu: Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, China
Yunfei Xu: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
Haoduo Qiao: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Haoduo Qiao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Haoduo Qiao: Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, China
Haoduo Qiao: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
Shun Yang: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Lin Zhou: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Lin Zhou: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Lin Zhou: Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, China
Lin Zhou: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
Yao Zhao: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Yao Zhao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Yao Zhao: Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, China
Yao Zhao: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
Qing Xu: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Qing Xu: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Qing Xu: Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, China
Qing Xu: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
Shuying Miao: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
Shuying Miao: Department of Pathology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
Dun Yuan: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Jie Zhao: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Ying Liu: Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China
Ying Liu: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China
Ying Liu: Sepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, China
Ying Liu: China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fneur.2022.893624
Journal volume & issue: Vol. 13

Abstract

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Background and PurposeStroke is a serious fatal and disabling disease. Stroke-associated pneumonia (SAP) is the most common complication of stroke, which may further aggravate the stroke. The prevention and early prediction of SAP is a key clinical strategy. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is involved in pneumonia, while its relationship with SAP has yet to be determined. Therefore, we investigated the predictive value of 15-PGDH for SAP and visualized their relationship.MethodsStroke patients were recruited and divided into SAP group and Non-SAP group. Baseline demographic and clinical data were obtained from the medical record system, blood samples were collected to detect relevant variables and 15-PGDH levels. Patient characteristics were compared with a t-test. Binary logistic regression analysis was performed to determine the predictive value of 15-PGDH for SAP. Restricted cubic splines (RCS) were performed to visualize the relationship between 15-PGDH and SAP risk. Finally, the SAP patient characteristics between the severe group and mild group were compared.Results50 patients were enrolled and divided into SAP group (n = 26) and Non-SAP group (n = 24). 15-PGDH in the SAP group was lower than that in the Non-SAP group (0.258 ± 0.275 vs. 0.784 ± 0.615, p = 0.025). Binary logistic regression analysis revealed that the lower 15-PGDH, the higher the risk of SAP (OR = 0.04, 95%CI, 0.010–0.157, p < 0.001). The RCS model showed the L-shaped relationship between 15-PGDH and SAP.ConclusionsIn stroke patients, serum 15-PGDH is a valuable biomarker for predicting SAP. There is an L-shaped relationship between the level of 15-PGDH and the risk of SAP.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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