Nature Communications (Nov 2022)
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection
- Lei Xu,
- Chuan Wei,
- Ying Chen,
- Yue Wu,
- Xiaoli Shou,
- Wenjie Chen,
- Di Lu,
- Haoran Sun,
- Wei Li,
- Beibei Yu,
- Xiaowei Wang,
- Xiaojun Zhang,
- Yanxiong Yu,
- Zhigang Lei,
- Rui Tang,
- Jifeng Zhu,
- Yalin Li,
- Linrong Lu,
- Hong Zhou,
- Sha Zhou,
- Chuan Su,
- Xiaojun Chen
Affiliations
- Lei Xu
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Chuan Wei
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Ying Chen
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Yue Wu
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Xiaoli Shou
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Wenjie Chen
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Di Lu
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Haoran Sun
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Wei Li
- Department of Clinical Laboratory, Nanjing First Hospital, Nanjing Medical University
- Beibei Yu
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Xiaowei Wang
- Department of Blood Transfusion, Children’s Hospital of Nanjing Medical University
- Xiaojun Zhang
- Imaging Center, Children’s Hospital of Nanjing Medical University
- Yanxiong Yu
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Zhigang Lei
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Rui Tang
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Jifeng Zhu
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Yalin Li
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Linrong Lu
- Institute of Immunology, School of Medicine, Zhejiang University
- Hong Zhou
- Department of Cell Biology, School of Life Sciences, Anhui Medical University
- Sha Zhou
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Chuan Su
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- Xiaojun Chen
- Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University
- DOI
- https://doi.org/10.1038/s41467-022-34660-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Immunosuppression as a result of severe infection impairs pathogen clearance and can increase susceptibility to secondary infection. Here, the authors dissect how T cell aging and the thymic involution that occurs during this process contribute to immunosuppression and find a key role for IL-33.
