Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-ones

Abstract

The reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-1,3-dimethylpiperazines (1 equiv), in THF, at ca. 20 °C gives (R) and (S)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4H-1,2,6-thiadiazin-4-ones in 70% and 68% yields, respectively. The new compounds were fully characterized.

Keywords

• substitution
• heterocycle
• thiadiazine
• piperazine
• chirality