570 Blockade of the inhibitory collagen receptor LAIR-1, PD-L1, and TGF-β promotes anti-tumor activity through T cell activation and myeloid cell polarization

• Jeffrey Schlom,
• Claudia Palena,
• Kristen Fousek,
• Lucas Horn,
• Dallas Flies,
• Solomon Langermann,
• Zachary Cusumano,
• Haiyan Qin,
• Han Myint,
• Masafumi Iida,
• Ronald Copeland

Affiliations

Jeffrey Schlom

Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, USA

Claudia Palena

Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, USA

Kristen Fousek

Aff1 grid.39382.33000000012160926XBaylor College of Medicine Houston TX USA

Lucas Horn

1National Cancer Institute, Bethesda, MD, USA

Dallas Flies

2NextCure, Beltsville, MD, USA

Solomon Langermann

2NextCure, Beltsville, MD, USA

Zachary Cusumano

1NextCure, Inc., Beltsville, MD, USA

Haiyan Qin

Department of Health Management, Shenzhen People`s Hospital, Second Clinical Medical College of Jinan University, First affiliated Hospital of South University of Science and Technology, Shenzhen, China

Han Myint

1NextCure LLC, Beltsville, MD, USA

Masafumi Iida

1National Cancer Institute, Bethesda, MD, USA

Ronald Copeland

2NextCure, Beltsville, MD, USA