Osteosarcoma in a patient with cranial fibrous dysplasia: a case report

Abstract

Fibrous dysplasia is a benign fibro-osseous lesion which rarely undergoes malignant transformation, frequently after radiotherapy. Osteosarcoma is the most common malignancy arising in fibrous dysplasia. We report a case of 67-year-old female patient with osteosarcoma developing in long lasting fibrous dysplasia without prior radiation. The patient underwent surgery with postoperative chemotherapy. She developed two relapses over the course of four years after the initial therapy. With this case, we want to underline the importance of noticing any significant change in the otherwise unremarkable course in patients with fibrous dysplasia.

Keywords

• Fibrous dysplasia
• Malignant transformation
• Osteosarcoma
• Radiotherapy