Nature Communications (Jun 2018)

A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes

  • Alexander Ohmann,
  • Chen-Yu Li,
  • Christopher Maffeo,
  • Kareem Al Nahas,
  • Kevin N. Baumann,
  • Kerstin Göpfrich,
  • Jejoong Yoo,
  • Ulrich F. Keyser,
  • Aleksei Aksimentiev

DOI
https://doi.org/10.1038/s41467-018-04821-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Mimicking enzyme function and improving upon it is a challenge facing nanotechnology. Here the authors design a DNA nanostructure that catalyzes the transport of lipids between bilayers at a rate three orders of magnitude higher than biological enzymes.