Nature Communications (Feb 2018)

LARP7 family proteins have conserved function in telomerase assembly

  • Laura C. Collopy,
  • Tracy L. Ware,
  • Tomas Goncalves,
  • Sunnvør í Kongsstovu,
  • Qian Yang,
  • Hanna Amelina,
  • Corinne Pinder,
  • Ala Alenazi,
  • Vera Moiseeva,
  • Siân R. Pearson,
  • Christine A. Armstrong,
  • Kazunori Tomita

DOI
https://doi.org/10.1038/s41467-017-02296-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.