DETERMINATION OF ACTIVITY OF INFLAMMATION IN INFECTIVE ENDOCARDITIS

Abstract

Aim. Study of diagnostic significance of serum level of tumor necrotizing factor a (TNF-a), C-reactive protein (C-RP) and procalcitonin (PCT) in infective endocarditis (IE).Methods. 66 patients with IE (60,6% male, 39,4% female), 35 with primary IE, 31 - with secondary IE, were included into the study. Clinical and laboratory investigation included determination of serum concentration of TNF-a, C-RP and PCT.Results. Dynamics of serum concentration of TNF-a, C-RP and PCT were described, types of changes of this parameters, which showed an unfavorable prognosis of infective endocarditis, were distinguished.Conclusion. Determination of serum level of TNF-a, C-RP and PCT can be used for description of the disease severity.

Keywords

• infective endocarditis
• diagnosis
• c-reactive protein
• tumor necrosis factor a
• procalcitonin